Innovation Overview

Pandorum Technologies, a Bengaluru biotech startup, has created a liquid cornea—a cell-free, injectable hydrogel made from biomaterials. The gel is applied as a liquid, fills corneal defects or ulcers, and solidifies in place. It supports native cell migration and tissue regeneration, restoring corneal transparency and vision without the need for full corneal transplant surgery.

How It Works

The liquid cornea acts as a scaffold, mimicking the natural extracellular matrix of the cornea. It promotes healing by allowing host corneal cells to repopulate the defect site. The product is transparent, biocompatible, and degrades naturally as new tissue forms. It can be used for partial-thickness defects, ulcers, and early-stage scarring.

Clinical Progress

Preclinical studies in rabbits and pigs showed complete regeneration of corneal epithelium and stroma within weeks, with restored transparency. Early human trials (compassionate use) in patients with corneal ulcers and perforations demonstrated significant vision improvement and healing without rejection or infection.

Addressing Corneal Blindness in India

India has the highest burden of corneal blindness globally, with over 10 million people affected and only ~25,000 donor corneas available annually against a need for 200,000+. Traditional keratoplasty (corneal transplant) faces long waiting lists, high cost, and risk of rejection. Liquid cornea could treat millions non-surgically or as an adjunct to reduce transplant dependence.

Expert Views

Dr. Tuhin Bhowmick (CEO, Pandorum): “This is a first-of-its-kind regenerative solution that could eliminate the need for donor tissue in many cases.”

Ophthalmologists note the potential to treat corneal ulcers early and prevent blindness progression.

Future Outlook

Pandorum plans larger clinical trials in 2026–27 and regulatory approval in India and globally. The product could be commercialized within 3–5 years if trials succeed.

Vibe View:

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